Beilstein J. Org. Chem.2024,20, 212–219, doi:10.3762/bjoc.20.21
efficient way for the synthesis of β-trifluoromethyl β-diacylamino esters. Furthermore, this reaction represents the first example of a Mumm rearrangement of β-trifluoromethyl β-diazo esters.
Keywords: β-carbonyldiazo; copper catalyst; fluoroalkyl diazo; Mumm rearrangement; unsymmetrical β-diacylamino
esters, which enriches the studied content of fluoroalkyl diazo compounds.
Results and Discussion
Due to the instability of β-carbonyldiazo compounds and the occurrence of possible side reactions [58][59][60][61], screening of reaction conditions to optimize this conversion and inhibit the occurrence of
][40][41][58][59], a possible mechanism for this Cu-catalyzed reaction of β-trifluoromethyl β-amino esters was proposed in Scheme 4. Initially, β-trifluoromethyl β-amino ester 1a reacts with tert-butyl nitrite to form trifluoromethylated β-carbonyldiazo intermediate A. Then, the diazo intermediate A
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Graphical Abstract
Scheme 1:
Mumm-type rearrangement of diazo compounds.